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1

Application of the Convection–Dispersion Equation to Modelling Oral Drug Absorption

Jan I. Freijer, Teun M. Post, Bart A. Ploeger, Joost DeJongh, Meindert Danhof

Journal:

Bulletin of Mathematical Biology

Year:

2007

Language:

english

File:

PDF, 245 KB

english, 2007

2

Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model

Flemming R. Cassee, Hans Muijser, Evert Duistermaat, Jan J. Freijer, Kees B. Geerse, Jan C. Marijnissen, Josje H. Arts

Journal:

Archives of Toxicology

Year:

2002

Language:

english

File:

PDF, 240 KB

english, 2002

3

Extensions to the Visual Predictive Check to facilitate model performance evaluation

Teun M. Post, Jan I. Freijer, Bart A. Ploeger, Meindert Danhof

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2008

Language:

english

File:

PDF, 498 KB

english, 2008

4

An example of optimal phase II design for exposure response modelling

Alan Maloney, Marloes Schaddelee, Jan Freijer, Walter Krauwinkel, Marcel van Gelderen, Philippe Jacqmin, Ulrika S. H. Simonsson

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2010

Language:

english

File:

PDF, 446 KB

english, 2010

5

Disease System Analysis: Basic Disease Progression Models in Degenerative Disease

Teun M. Post, Jan I. Freijer, Joost DeJongh, Meindert Danhof

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 777 KB

english, 2005

6

Pharmacokinetic Modeling of Non-Linear Brain Distribution of Fluvoxamine in the Rat

Marian Geldof, Jan Freijer, Ludy van Beijsterveldt, Meindert Danhof

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 540 KB

english, 2008

7

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development

Ashley Strougo, Thomas Eissing, Ashraf Yassen, Stefan Willmann, Meindert Danhof, Jan Freijer

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2012

Language:

english

File:

PDF, 311 KB

english, 2012

8

Population pharmacokinetic model of fluvoxamine in rats: Utility for application in animal behavioral studies

Marian Geldof, Jan Freijer, Ludy van Beijsterveldt, Philip Timmerman, Abdellah Ahnaou, Wilhelmus H.I.M. Drinkenburg, Meindert Danhof

Journal:

European Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 632 KB

english, 2007

9

Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex

Marian Geldof, Jan I. Freijer, Lambertus A. Peletier, Ludy van Beijsterveldt, Meindert Danhof

Journal:

European Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 695 KB

english, 2008

10

Pharmacokinetic–pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior

Marian Geldof, Jan Freijer, Ludy van Beijsterveldt, Patrick C.M. Vermote, Anton A. Megens, Meindert Danhof

Journal:

European Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 810 KB

english, 2007

11

Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics

Dorien Groenendaal, Jan Freijer, Andrea Rosier, Dennis de Mik, Glynis Nicholls, Anne Hersey, Andrew D. Ayrton, Meindert Danhof, Elizabeth C.M. de Lange

Journal:

European Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

12

Novel Δ9-tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects

Linda E. Klumpers, Tim L. Beumer, Johan G. C. van Hasselt, Astrid Lipplaa, Lennard B. Karger, H. Daniël Kleinloog, Jan I. Freijer, Marieke L. de Kam, Joop M. A. van Gerven

Journal:

British Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

13

Risk Assessment in Extrapolation of Pharmacokinetics from Preclinical Data to Humans

Zvi Teitelbaum, Thierry Lave, Jan Freijer, Adam F. Cohen

Journal:

Clinical Pharmacokinetics

Year:

2010

Language:

english

File:

PDF, 230 KB

english, 2010

14

Calibration of Jointed Tube Model for the Gas Diffusion Coefficient in Soils

Freijer, Jan I.

Journal:

Soil Science Society of America Journal

Year:

1994

Language:

english

File:

PDF, 377 KB

english, 1994

15

Modeling the Gas Diffusion Coefficient in Analogy to Electrical Conductivity Using a Capillary Model

Weerts, Albrecht H., Freijer, Jan I., Bouten, Willem

Journal:

Soil Science Society of America Journal

Year:

2000

Language:

english

File:

PDF, 213 KB

english, 2000

16

Analysis of Lobar Differences in Particle Deposition in the Human Lung

Subramaniam, Ravi P., Asgharian, Bahman, Freijer, Jan I., Miller, Frederick J., Anjilvel, Satish

Journal:

Inhalation Toxicology

Year:

2003

Language:

english

File:

PDF, 183 KB

english, 2003

17

Modeling Relationships between Indoor and Outdoor Air Quality

Freijer, Jan I., Bloemen, Henk J.Th.

Journal:

Journal of the Air & Waste Management Association (1995-)

Year:

2000

Language:

english

File:

PDF, 235 KB

english, 2000

18

Predicting the “First dose in children” of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages

Strougo, Ashley, Yassen, Ashraf, Monnereau, Claire, Danhof, Meindert, Freijer, Jan

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 710 KB

english, 2014

19

Profiling the subjective effects of Δ 9 -tetrahydrocannabinol using visual analogue scales

Kleinloog, Daniël, Roozen, Frits, De Winter, Willem, Freijer, Jan, Van Gerven, Joop

Journal:

International Journal of Methods in Psychiatric Research

Year:

2014

Language:

english

File:

PDF, 587 KB

english, 2014

20

Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics

Heuberger, Jules A. A. C., Guan, Zheng, Oyetayo, Olubukayo-Opeyemi, Klumpers, Linda, Morrison, Paul D., Beumer, Tim L., van Gerven, Joop M. A., Cohen, Adam F., Freijer, Jan

Journal:

Clinical Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 905 KB

english, 2015

21

Monitoring Prednisolone and Prednisone in Saliva

Teeninga, Nynke, Guan, Zheng, Freijer, Jan, Ruiter, An F. C., Ackermans, Mariëtte T., Kist-van Holthe, Joana E., van Gelder, Teun, Nauta, Jeroen

Journal:

Therapeutic Drug Monitoring

Year:

2013

Language:

english

File:

PDF, 473 KB

english, 2013

22

Mineralization of Hydrocarbons in Soils under Decreasing Oxygen Availability

Freijer, Jan I.

Journal:

Journal of Environmental Quality

Year:

1996

Language:

english

File:

PDF, 229 KB

english, 1996

23

Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population

Watson, Estelle, Khandelwal, Akash, Freijer, Jan, van den Anker, John, Lefeber, Claudia, Eerdekens, Mariëlle

Journal:

Journal of Pain Research

Year:

2019

File:

PDF, 2.60 MB

2019

24

Population Pharmacokinetics of Tapentadol in Children from Birth to

Khalil, Feras, Choi, Siak Leng, Watson, Estelle, Tzschentke, Thomas M, Lefeber, Claudia, Eerdekens, MariÃ«lle, Freijer, Jan

Journal:

Journal of Pain Research

Year:

2020

File:

PDF, 2.56 MB

2020